7/1/2023 Methods for treating myocardial infarction comprising adminis... by Alain LacampagneRead Now![]() The GRMD mimics more closely the human disease of DMD compared to other existing mammalian models of dystrophin deficiency. Similar to rodent models of heart failure, the gradient of transmural contractility is altered in Golden Retriever muscular dystrophy (GRMD) dogs. Myofilament contractile heterogeneity is also observed in the heart of healthy Golden Retriever dogs. ![]() This gradient of contractility is significantly reduced in ischemic heart failure, caused, mainly, by failure in the ENDO layer contractile efficiency. The inner LV layer (Endocardium, ENDO) develops higher passive and active contractile properties, when compared to the outer LV layer (Epicardium, EPI),. In most species, the left ventricle (LV) is characterized by a gradient of contractility across its free wall. Thus, the cellular molecular mechanisms underlying this myopathy-linked myocardial contractile disorder are poorly understood and yet to be discovered. ![]() Only a few studies have examined the impact of DMD on cardiac contractility. Heart failure constitutes, together with respiratory failure, the main leading cause of mortality in patients with muscular dystrophy. This pathology is characterized by loss of dystrophin protein, a protein involved in striated muscle structure and function maintenance. ![]() Duchenne Muscular Dystrophy (DMD) is an X-linked genetic mutation and lethal muscular disorder. ![]()
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